Subcutaneous vs intramuscular testosterone reddit We performed a scoping review of the available data on estradiol levels achieved with various dosages of estradiol injections in transgender and gender diverse adults on feminizing gender-affirming hormone therapy. Most clinics up to speed on the latest approaches recommended sub q and more frequent injections. This subreddit is for questions and discussion related to testosterone replacement therapy and testosterone. Intramuscular vs Subcutaneous Hey guys, I am currently on intramuscular injections. May 2, 2025 · Q: Why is subcutaneous testosterone considered a better option compared to intramuscular injections? A: Subcutaneous testosterone is associated with less tissue damage, more stable hormone levels, and a lower risk of side effects such as thick blood and sleep apnea, making it a preferable method for many patients. Sep 26, 2023 · The Role of Subcutaneous vs. Apr 7, 2019 · How does anyone here on hGH do their injections? Via subcutaneous or intramuscular? I have done both and noticed no difference but I was reading about how an IM injection is better than a SubQ one because it gets into your bloodstream faster and works better. Prescriber sends over subcutaneous needles and has directions to inject it subcutaneously. The objective was to compare the SC and IM E2 doses and hormone levels in transgender and gender diverse individuals. With administration using either route, the ester exits the depot via diffusion into the interstitium, from where it enters Oct 10, 2024 · Testosterone Replacement Therapy (TRT) is a popular treatment option for individuals with low testosterone levels. Subcutaneous At AlphaMD. 5-inch syringe. Oct 12, 2020 · I'm confused about how to inject HCG. Participants Twenty men (11 Aug 13, 2021 · The results showed that men who underwent SubQ injections of testosterone resulted in a 14% greater increase in total testosterone levels than the testosterone level of IM patients. Oct 26, 2021 · Conclusion: Although studies directly comparing the safety of subcutaneous vs intramuscular administration of testosterone esters are desirable, clinicians should consider discussing the subcutaneous route with their patients, as it is easier to self-administer and has the potential to improve patient adherence. Also I don't think the testosterone would be any different for subq vs Intramuscular? Or at least I've never heard of it, it doesn't really make sense to me for them to be different Jul 24, 2021 · Subcutaneous or SubQ testosterone injections are quickly gaining in popularity by doctors and patients as the easiest way to self administer Testosterone Replacement Therapy (TRT). I described how the cumulative damage to poking your muscle Feb 18, 2024 · In summary, the main differences between subcutaneous and intramuscular injection of testosterone cypionate lie in the rate of absorption, injection site reactions, and convenience. Can anyone break down the benefits for me please? We would like to show you a description here but the site won’t allow us. Learn the pros and cons of each for stability, comfort, and ease of use. 75 vs 4 mg). We compare Hey friend, normally for testosterone 25g needles are prescribed from a clinician (local laws sometimes require the prescription). Mar 24, 2025 · Excerpt from our second Reddit AMA podcast video: When it comes to doing TRT injections, what's better; IM or SubQ? Transcript This editable transcri We would like to show you a description here but the site won’t allow us. Why is that? Are there any differences in how the T affects you? Or is it maybe an insurance thing? Subcutaneous Vs. Let's share experiences and insights! There is nothing to settle in the IM vs SubQ debate. Testosterone products are measured in milligrams (mg). Here is a quick example of how I metabolize T differently, depending on injection type. My doctor said it would be the best route for keeping me levels consistent, because the fat helps it release slower. Is there a difference in testosterone cyp that is gong to be injected subcutaneous vs intermuscular? I have started doing subcutaneous injections and noticed a red itchy spot on my skin a couple days after injection. Hi, I am aware of and experienced with injecting peptides like ghrp subcutaneous, but i very recently came to know that even oil based testosterone can be injected subcutaneous route. subcutaneous is that intramuscular hurts more during the process and leaves a slightly different feeling or ache afterward. Design Randomized sequence, crossover clinical study of SC vs IM TU injections. Jul 26, 2025 · Compare subcutaneous (SubQ) vs. Also just wanted to say I'm not on a cycle, am on trt for life. ST and subcutaneous adipose layer thickness (SCT) were measured in adults with diabetes. New comments cannot be posted and votes cannot be cast. Never seen SQ admin before, box says for intramuscular injection only. Nov 29, 2024 · Discover the key differences between subcutaneous and intramuscular injections for testosterone replacement therapy (TRT), and why Sub-Q injections may offer a simpler, effective option. my testosterone says intramuscular use only, as most t does, regardless of it being sub q or im. 5) Subcutaneous injection is a particularly easy direction to go for those who have been taking pills. Oct 5, 2023 · Abstract Objectives: This prospective study compares testosterone injection type and effects on biochemical changes, clinical effects, and quality of life amongst transgender and gender diverse (TGD) adolescents assigned female at birth (AFAB) over the first 6 months of subcutaneous (SQ) vs. These injections can be administered via subcutaneous (under the skin) or intramuscular (into the muscle) methods at various sites on the body. im is generally absorbed more quickly due to a greater vasculature within muscles, while subq can be more gradual (up to 24 hours) because there's not as much blood supply throughout the subcutaneous layer of fat. It comes down to absorption rates mainly. They found subcutaneous administration of testosterone to be a safe, effective, and affordable alternative to IM injection. I'm doing 250mg a week, two 125mg injections a week. 4 mL, 21g 1. Is SQ a valid option for testosterone cyp? This subreddit is for questions and discussion related to testosterone replacement therapy and testosterone. Sep 1, 2025 · Testosterone is a male hormone responsible for the growth and development of the male sex organs and maintenance of secondary sex characteristics. During the past five years Hello everyone, wondering if anyone has experience with intramuscular vs subcutaneous daily testosterone Cyp and their levels. Doctors have preferred administering intramuscular (IM) injections for a very long time because they thought that by injecting deeper into the muscle, testosterone delivers into the blood stream easier and stays in I've been rotating IM injections between delts and ventroglutes every 3. 5" needle; my fiance's is subq, weekly, 0. If you're using an insulin syringe, these are labelled in units because they're designed to be used with U100 insulin (100 units per millilitre insulin). For TRT purposes the slower absorption is better for me personally as it keeps levels more stable with more even peaks and troughs Vs IM Everyone is different though and for some IM works better. The results showed that men who underwent SubQ injections of testosterone resulted in a 14% greater increase in total testosterone levels than the testosterone level of IM patients. When it comes to administering TRT, two primary methods are commonly used: subcutaneous (under the skin) and intramuscular (into the muscle) injections. Nov 12, 2020 · The FOLX HRT injection guide for SubQ and IM injections for HRT/GAHT. Medication delivered this way is more slowly absorbed into the bloodstream than medication that is directly injected into the muscle. Which do you guys recommend and why? Abstract Purpose: Intramuscular testosterone cypionate (IM-TC) is known to cause significant rises in estradiol (E2), hematocrit (HCT), and prostate specific antigen (PSA) due to its supraphysiological testosterone peaks, whereas a novel subcutaneous testosterone enanthate autoinjector (SCTE-AI) was designed with a lower testosterone peak-to-trough ratio to mitigate these reactions. It involves the administration of exogenous testosterone to supplement the body’s natural production. The primary aimwas to compare the doses between the SC and IM routes and the serum E2 and testosterone levels in TGD individuals. 25" needles recommended as very sharp and low pain. The secondary goals included comparing the effect of antiandrogens, gonadectomy status, and the use of E2 cypionate vs valerate on doses between SC administration and IM administration. It’s important you discuss needle length with your clinician because depending on your body you may need a 1 In this video I compare IM to SubQ TRT blood labs. intramuscular (IM) testosterone injections as part of their gender affirming care. When it comes to administering TRT, there are two main methods: Subcutaneous (SubQ) and Intramuscular (IM) injections. So I’ve found this study on subq enanthate: We would like to show you a description here but the site won’t allow us. Intramuscular vs subcutaneous? From what I’ve read/heard, subQ seems much less painful and invasive, but I still see people saying they do IM over SubQ. Just looking for advice on what’s the best protocol for injection sites. I just saw another post about the opposite happening to someone too. I'm currently preparing to change from bi-monthy doses to daily doses from studies I've been reading (and reddit posts) but am pondering between the two different ways of injecting. 9K subscribers Subscribe IM testosterone hits its Cmax at day 4 or 5, while SubQ hits Cmax around 24 hours. Intramuscular and Subcutaneous. Not to get too detailed, I was wondering the major differences between SubQ and Intramuscular? Is it true intra will spike your test higher than subq? Is it also true that subq will keep a more steady level of testosterone until your next injection? Jul 26, 2025 · Compare subcutaneous (SubQ) vs. My question is, is there a large difference between this injection method and muscular? I’m eager (as I’m sure most trans guys/non-binary folk are when they first start their transition) for changes, so I wanted to know if anyone has experience Abstract Context Can injectable testosterone undecanoate (TU) be administered effectively and acceptably by the subcutaneous (SC) route? Objective To investigate the acceptability and pharmacokinetics (PK) of SC injection of TU. SC may achieve therapeutic levels at lower doses than IM . I know I have some options with frequency of dose, but all things equal which injection model has less aromatization? You can use either, but 25g is smaller which means it'll take a bit longer to inject (because testosterone is thick and it's harder to push it out of a smaller needle) whereas 23g is a bit bigger and will be a bit faster. 4 Choose Injection Site There are two ways to inject hormones: Intramuscular (IM) and Subcutaneous (SubQ) Oct 24, 2013 · In a study initiated by the well-known endocrinologist, Dr. I was thinking about trying SubQ EoD or ED for easier injections, steady levels, and less waste with insulin syringes. " Intramuscular Injections I've seen Nipro 27g 1. The main hypothesis is that if subcutaneous injections absorb slower than IM, subq injections will elongate propionate half life more than 0. Mar 4, 2021 · STUDY: Subcutaneous Injection of Testosterone Is an Effective and Preferred Alternative to Intramuscular Injection: Demonstration in Female-to-Male Transgender Patients (Spratt 2017) Dec 8, 2022 · Gender-affirming hormone therapy guidelines describe the estradiol (E2) doses for intramuscular (IM), but not subcutaneous (SC), routes. Understanding Testosterone Injection Therapy Testosterone injections are a widely used form of Testosterone Replacement Therapy. Why does psychonaut make it sound like subq injection is so much more dangerous than IM injection? I would think I would rather have an issue with my subq tissue than with a muscle! Also is much easier to execute. com A study conducted by the Department of Urology at University of California found that subcutaneous (subQ) injections (under the skin rather than into the muscle) led to higher levels of free T, along with evidence of subQ being physiologically superior to IM shots in several other important ways. Also, you get the same amount of testosterone into your system with lower doses when injecting subq testosterone into your system with subq vs IM (in order words, if you inject 100mg IM and 100mg subq, you’ll get more T into your system with subq). Currently on Subq to let the scar tissue heal. We would like to show you a description here but the site won’t allow us. Dec 4, 2024 · My endo told me to up my dose on SubQ now. The method of administration can affect the absorption rate and potentially the effectiveness of the testosterone. Thank you for your patience! Nov 1, 2017 · Generally, those over age 40 should be on a parenteral regimen, not an oral one. You can use either, but 25g is smaller which means it'll take a bit longer to inject (because testosterone is thick and it's harder to push it out of a smaller needle) whereas 23g is a bit bigger and will be a bit faster. My prescription says to inject it intramuscular, but everything I read on this site, says it should be injected subcutaneous. Second pic, is 8 weeks of IM injections. You use a shorter needle, and switch up the places to be the four quadrants of the belly each time you dose. 5% lower E2 levels. I actually spoke to Dave Palumbo Subcutaneous vs Intramuscular Testosterone Injections: Which is better? Estradiol Valerate Injection Med-ed Instructional Video by ReUnite Rx Hormone Self-Injection - Step 2a: Intramuscular Injection Mar 24, 2025 · Understanding Testosterone Injection Methods: Intramuscular vs. It's a smaller needle for sub-q, because it only needs to go under the skin into the fat and not all the way down into the muscle. 3 mL (had Nov 15, 2020 · Comparison of Outcomes for Hypogonadal Men Treated with Intramuscular Testosterone Cypionate Versus Subcutaneous Testosterone Enanthate (2020) Introduction Intramuscular testosterone cypionate (IM-TC) is the conventional treatment option for hypogonadal men with baseline serum total Yeah you're totally fine, mine says the same thing but my doctors gave my subq needles. 2 points out of This subreddit is for questions and discussion related to testosterone replacement therapy and testosterone. Need another reason? How about it’s less painful and forms less scar tissue. 4 Choose Injection Site There are two ways to inject hormones: Intramuscular (IM) and Subcutaneous (SubQ) Jan 30, 2025 · Subcutaneous injections are given into the fat layer under the skin, while Intramuscular injections are administered into the muscle. I find that subcutaneous hurts less during the process, but leaves residual soreness or irritation. Subcutaneous injection offers a slower release of testosterone, fewer injection site reactions, and easier administration for individuals who prefer to self-administer. Intramuscular I do subcutaneous in my stomach. Both of these can be self-administered at home by yourself or with the help of a friend or family member. 3ML (60mg) into my tummy weekly. I read an article on this site about the benefits of subcutaneous and lower hematocrit levels and other pluses. On-label use is "for intramuscular use only. Check your testosterone levels now with Lets Get Checked, here: https://trylgc. Danny Bossa explains explains subQ vs IM Testosterone Replacement Therapy TRT, and why he changed from TRT subcutaneous injections to IM testosterone injections. Text C, 40mg e/o/d at 8-9pm. To those of you who have tried both, is there a difference to you? Feb 17, 2022 · Although studies directly comparing the safety of SC vs IM administration of testosterone esters are desirable, clinicians should consider discussing the SC route with their patients because it is easier to self-administer and has the potential to improve patient adherence. Bloodwork taken at 8am the morning after a pin. Testosterone injection is also used in women with breast cancer that has spread to other parts of the body (metastatic). Subcutaneous vs Intramuscular Testosterone Injections: Which is better? Man Medicine 13. But plenty of people do subq (myself included), and it works just as well as IM! For those of you who do injections (SubQ or IM) for T, what gauge needle? We would like to show you a description here but the site won’t allow us. . Additionally, understandin This subreddit is for questions and discussion related to testosterone replacement therapy and testosterone. testosterone cypionate is not approved by the FDA for subcutaneous injection. Dec 4, 2024 · I'd like to start a discussion here for anyone debating between subcutaneous and intramuscular injections. SubQ patients also resulted in a 41% lower hematocrit post-therapy than IM patients and 26. I believe it can be used for subcutaneous injection as well. Intramuscular is the traditional way to inject, and subcutaneous is more of a new and rising practice. Sun-q should not have a meaningful effect on total test levels vs an IM injection. Not to get too detailed, I was wondering the major differences between SubQ and Intramuscular? Is it true intra will spike your test higher than subq? Is it also true that subq will keep a more steady level of testosterone until your next injection? I did some research and found out there are two ways of injection for testosterone. 2014 Apr-Jun;60 (2):175-8. So with weekly injections at test day SubQ your levels have been falling all week, and with IM your levels have just started falling. See full list on hrtdoctorsgroup. 100% subq: slower release = more even levels. SubQ patients also had 41% lower hematocrit post-therapy than IM patients and 26. Is it just an attempt to mimic normal test cycles/not yo-yo? Pros and cons to either? I’m comfortable with intramuscular should I do one over the other? Is there a significant difference between intramuscular and subcutaneous injection of testosterone in terms of absorption or possible problems, and which do you think is the proper way to inject? Archived post. intramuscular (IM) injections for TRT. my shot is im, weekly, 0. MembersOnline upvotes ·comments r/Testosterone This subreddit is for questions and discussion related to testosterone replacement therapy and testosterone. It's not the technique too because its not my first time doing Subq, I've done it before with Hcg. TRT Treatment Explained The benefits, risks, and side effects of TRT, what blood work you need, and how to interpret lab results without a doctor. At present, many new transsexual men are being started on subcutaneous Testosterone Cypionate injections instead of IM in the Northern California area. For both groups of men, there were no elevated levels of PSA” Anyone have evidence of SubQ vs IM - which one raises T levels more? Intramuscular vs subcutaneous for testosterone? Just prescribed testosterone doctor told me to do twice weekly injections in my stomach. org, we understand that personalized treatment is key in testosterone replacement therapy (TRT). Finally got a dr to prescribe me test they’re telling me to do daily subcutaneous. Which between Testosterone Pellets Vs Injections is better? Dec 31, 2013 · Pain or swelling at injection site. Feb 16, 2023 · No matter what kind of TRT your doctor has given you, a common question is where to inject testosterone. it probably was absorbed subq rather than im but that shouldn't make much of a difference. Self-inject estrogen and testosterone safetly and comfortably. IM is faster, subq is slower. I've been messing around with subq for ketamine because I'm tired of clogging up my nose, but wanted to assess the risk - I use sterile one-time needles, 0. com/Entrepreneurs - Use coupon code Unlike subcutaneous injections, intramuscular testosterone injections deliver the hormone directly into muscle tissue, usually in the thighs or buttocks. One benefit is that enanthate is double the concentration of cypionate, so your injections use less liquid. A, Illustration of the progressive increase in lipophilicity of testosterone esters with increase in number of carbons in the side chain. Intramuscular Injections in Testosterone Replacement Therapy (TRT) Testosterone Replacement Therapy (TRT) is a medical treatment used to address low testosterone levels in men. I had my first shot a few days ago. “When the hormone is given by injection, the subcutaneous route is preferable to the intramuscular one, as the subcutaneous route provides for a longer duration of action and thus is more effective per given dose. (ref. Which between Testosterone Pellets Vs Injections is better? Why does psychonaut make it sound like subq injection is so much more dangerous than IM injection? I would think I would rather have an issue with my subq tissue than with a muscle! Also is much easier to execute. Concerning its effective dose, one study summarized here actually found that subcutaneous injection produced higher T levels than the equivalent dose done as an intramuscular injection. Hey guys! So I just started HRT, testosterone cypionate and I’m injecting 0. For decades, most men have injected their testosterone intramuscularly (IM), primarily into the glutes, quadriceps, or deltoids, using a 1 to a 1. Nov 22, 2016 · Click here to watch videos on how to inject testosterone intramuscularly or subcutaneously More information on subcutaneous testosterone injections Intramuscular is the traditional way to inject, and subcutaneous is more of a new and rising practice. 22 micron filter, and Jun 30, 2021 · Is there really a difference in absorption? I’ve had a couple of Dr’s say only intramuscular. A HORMONE INJECTION SUBCUTANEOUS (SUBQ) WHAT IS A SUBCUTANEOUS INJECTION? A subcutaneous injection, delivers medication into the subcutaneous layer of tissue that is directly under the skin. The length of the needle may vary a bit depending on how much fat you have as you need to go through the fat and into the muscle below. So that's one finding. Sep 1, 2024 · We performed a scoping review of the available data on estradiol levels achieved with various dosages of estradiol injections in transgender and gender diverse adults on feminizing gender-affirming hormone therapy. MembersOnline aromatization with intramuscular vs subcutaneous? So I appear to be sensitive to TRT aromatization wise. : r/Testosterone Scan this QR code to download the app now Or check it out in the app stores TOPICS Gaming Sports Business Crypto Television Celebrity POPULAR POSTS Copy This subreddit is for questions and discussion related to testosterone replacement therapy and testosterone. The results showed that men who underwent SubQ injections of testosterone resulted in a 14% greater increase in total testosterone levels than the testosterone level of IM patients. 5 days. Dec 27, 2020 · by TC Luoma How to easily wipe out the possible negative side effects of testosterone replacement therapy with one simple adjustment. not for nothing but I too was hesitant about intramuscular injections in the thigh, and I found out that estradiol valerate (which the printed label says is for IM injections) can also be used subcutaneously into belly fat. This can cause an inflammatory reaction in the leg resulting in discomfort and decreased testosterone effect. Same details apply. Felt a lot better on IM. ” J Postgrad Med. 29g for testosterone cypionate subcutaneous and 30g for HCG (also subcutaneous). For estrogen I’ve seen 23-25g needles issued as prescriptions, I personally use 23g (I experience no discomfort when I inject my medication properly). Cypionate is cottonseed oil, that's correct. If pain at the injection site develops the day after injection that lasts for several days the medication may have been injected into subcutaneous tissue (fat) instead of into muscle. What little experience I have of intramuscular vs. It also focuses on lifestyle activities like exercise and nutrition for raising testosterone levels naturally or anything else related to testosterone the substance. Whether using the intramuscular (IM) or subcutaneous (SubQ) method, following correct techniques and safety guidelines is crucial. But the injection supplies you use for subcutaneous vs intramuscular injections are different. May 17, 2023 · Testosterone replacement therapy (TRT) plays a crucial role in improving men's health by addressing hormonal imbalances. Low Testosterone & TRT Basics What causes low T, how to diagnose it, what symptoms to look for, and why the “normal” testosterone range is misleading. First pic, is 8 weeks of SubQ injections. It’s not even There is no specific type of solution relating to IM vs subq. " Sure we know it is perfectly fine, but most doctors prescribe testosterone the way the FDA approved it to be prescribed, and most people take their meds the way doctors prescribe it to them. I heard somewhere that there’s a better method using diabetic needles and administering subcutaneous. I have 3 questions: 1-Which type of injection is better and causes better results? 2-Is it possible to do a subcutaneous injection using testosterone enanthate? 3-Is there any testosterone exclusively for Subcutaneous injection? Had a script sent in the other day for testosterone cyp 200mg/ml. and i don't believe belly hair has anything to do with the t being injected into your stomach btw. Testosterone enanthate is suspended in sesame oil, so you should give that a try if you're not also allergic to sesame. We also report on testosterone suppression, route (ie, subcutaneous vs intramuscular), and type of injectable estradiol ester as well as timing of blood draw relative to the most Both the SC and IM E2 achieve therapeutic E2 levels without a significant difference in the dose (3. Setting Ambulatory clinic of an academic andrology center. We also report on testosterone suppression, route (ie, subcutaneous vs intramuscular), and type of injectable estradiol ester as well as timing of blood draw relative to the most wondering what the pros and cons of both injection methods are for testosterone-- does one work better than the other? does it depend on how often you do the injections and the dosage? I am prescribed test cypionate, and I administer it intramuscular. Norman Spack, researchers sought to assess the safety and absorption of subcutaneous testosterone therapy in FTM trans men and hypogonadal cis gender men. reddit We would like to show you a description here but the site won’t allow us. Below is a detailed guide on how to properly administer testosterone injections and understand the key differences between stomach is sub q. B, Schematic illustration of the absorption steps of testosterone esters after intramuscular (left) or subcutaneous (right) injection. Introduction Those of you on testosterone, what’s your preferred method of taking it and why? Aug 11, 2024 · Conclusion: Injecting Testosterone Knowing how to properly inject testosterone is essential for individuals undergoing hormone replacement therapy. To note, I felt really zero difference day to day between these two different regimens. I got a phone call appointment with my doctor, discussed the difference between subcutaneous injections and intramuscular injections, laughing about how intramuscular would be too painful so I didn’t want that and told him I wanted subcutaneous, and it was agreed upon that I would get subcutaneous and get training for injections. I’ve written before about how subcutaneous (under the skin) injections are more convenient and less problematic than intramuscular injections for men undergoing testosterone replacement therapy (TRT). the t isn't a local substance just to the area it was injected. Nov 14, 2024 · TRT is one of the most effective ways to improve the life quality you are experiencing. The only reason all T vials say "for IM use only" is because subcutaneous T injections aren't technically approved by the fda or something. Also, my H&H crept up . Site will be available soon. I have a cut mix 400mg/ml, each ML of which has 100 mg Testosterone Propionate 100 mg of Tren Acetate 100 mg of Primobolan 100 mg of Masteron I take it 1 ml intramuscular twice a week as I'm on a low dose cycle subcutaneous injection vs intramuscular Been taking test for like ten weeks doing IM injections. Because muscles have a denser blood supply compared to fat tissue, testosterone is absorbed faster into the bloodstream, leading to a quicker onset of its effects. We also report on testosterone suppression, route (ie, subcutaneous vs intramuscular), and type of injectable estradiol ester as well as timing of blood draw relative to the most recent dose, where available. 8 days (19-20h). Jul 3, 2023 · There are two methods for delivering testosterone or estrogen with needles: subcutaneous (Sub-Q) injections or intramuscular (IM) injections. I've heard SQ dosing can cause inconsistent levels. sbqvo fyqdvx emn scej okqv lfh zynaj mide oljs bpyk vhy vyj ntsywih apnpqid isuhxxdq